Sweating and Beta-Adrenoceptor Antagonists

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Alpha- and beta-adrenoceptor antagonists.

Antagonists acting on the betaor alphaadrenoceptors are used widely in medicine and in anaesthesia. The major indications for betaadrenoceptor blockade are coronary artery disease and arterial hypertension, while those for alphaadrenoceptor blockade include arterial hypertension, paroxysmal hypertension and chronic cardiac failure. The adrenoceptor antagonists interfere with important regulator...

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Adrenoceptor Antagonists

Drugs that produce responses by interacting with adrenoceptors are referred to as adrenoceptor agonists or adrenergic agonists. Norepinephrine and isoproterenol are examples of such compounds. Agents that inhibit responses mediated by adrenoceptor activation are known as adrenoceptor antagonists, adrenergic antagonists, or adrenergic blocking agents. Prazosin and propranolol are examples of rec...

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TEACHERS’ TOPICS Antianginal Actions of Beta-Adrenoceptor Antagonists

Angina pectoris is usually the first clinical sign of underlying myocardial ischemia, which results from an imbalance between oxygen supply and oxygen demand in the heart. This report describes the pharmacology of b-adrenoceptor antagonists as it relates to the treatment of angina. The b-adrenoceptor antagonists are widely used in long-term maintenance therapy to prevent acute ischemic episodes...

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Lipophilic beta-adrenoceptor antagonists and local anesthetics are effective direct activators of G-proteins.

We studied the effects of various beta-adrenoceptor (beta AR) antagonists and local anesthetics (LAs), i.e. substances possessing one basic and one lipophilic domain each, on activation of regulatory heterotrimeric guanine nucleotide-binding proteins (G-proteins). In membranes of differentiated HL-60 cells, propranolol activated high-affinity GTP hydrolysis with a half-maximal effect at 0.19 mM...

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Potentially hazardous co-prescribing of beta-adrenoceptor antagonists and agonists in the community.

AIM The aim of this study was to investigate the co-prescribing of beta-antagonists and beta-agonists in the community, and to assess the potential hazards of such co-prescribing. METHODS The study was set in the population of Tayside, Scotland (population approximately 400,000), between January 1993 and March 1993. An automated person-specific prescribing database was used, which could also ...

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ژورنال

عنوان ژورنال: Dermatology

سال: 1995

ISSN: 1018-8665,1421-9832

DOI: 10.1159/000246645